This gastric biopsy was taken from an asymptomatic 30-year-old woman with a familial history of hereditary diffuse gastric carcinoma. Slide A was stained with hematoxylin and eosin, and slide B was stained immunohistochemically with the antibody to cytokeratin CK7.

Mutation of which gene most likely accounts for the pathologic changes seen in this biopsy?

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